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Systematic analysis of immunotherapy efficacy with concomitant antibiotics use: Role of gut microbiome in cancer immune response.

Background: Intestinal microbiota can modulate immune mediated effects of anticancer therapies. Research suggests that efficacy of CTLA-4 blockade and anti-PD-1/PDL-1 drugs may depend on gut microbiota through enhancement of T-cell or dendritic cell function. Interactions of antibiotic and probiotic therapy with cancer immunotherapies have been retrospectively studied and are controversial. The purpose of our study is to assess the impact of antibiotics on cancer immunotherapy treatment. We conducted a systematic analysis of literature analyzing the effects of antibiotic usage on cancer immunotherapy outcome in animal tumor models and patients with advanced malignancies. We searched pubmed, American Society of Clinical Oncology and American American Association for Cancer Research websites

Author(s):

Vignesh Krishnan

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