Insights in Blood Pressure

With space flight (SF) significant reductions of serum Mg (P < 0.0001) despite poor serum sensitivity, shown in space shuttle crew members. Mg, a strong antioxidant and calcium blocker; with SF, there is oxidative stress, insulin resistance, inflammatory conditions; in experimental animals significant endothelial injuries to mitochondria, reductions in transferrin and in turn oxidative stress.  Inhalation of Lunar iron (Ir) particulate matter contributes to stress test - hypertension on Earth return (ER): James Irwin’s blood pressure (BP) 275/125 after 3 minutes of exercise (ER); Neil Armstrong showed very high diastolic BP 160/135 on ER,  consistent with impaired cardiac function. Magnet (M) studies of value on moon; similarly, M studies on Earth used to quantitate high indoor Ir levels. Since over 90 % of brakes made of Ir, combination Ir brake dust inhalation and Mg deficiencies in over 60% U.S. population, may be important factors intensifying worldwide hypertension.