Insights in Blood Pressure

Chronic Permanent Nonvalvular Atrial Fibrillation and Inflammatory Syndrome. It Is Possible a Contribution of Dental State to Sustain and Exacerbate Inflammation?

The intervention of dental state (altered by chronic gum infections:  parodontosis, gingivitis, parodontitis and carries) in cardiovascular disease (CVD) is now still in disputation. We think that, in patients with CVD and chronic nonvalvular atrial fibrillation (CAF), dental state may play a role in pathogenesis by increase of chronic low-level inflammation.

In a cross-sectional study, we analyzed 1081 patients (age: 69 years, male=323-29%) with CVD by clinical and laboratory investigations; 176 patients have CAF (mean age 69 years, male=40-22,7%), compared with the rest of 936 no CAF patients (mean age 57 years, male 323 (34,5%). Chronic inflammation was detected by serum fibrinogen (sF), leukocytes, CRP level, BSR. Dental state was an index calculated by sum of missing teeth with non-treated carries, already used early in other studies.

Results: statistically, chronic inflammation in CAF group  differs from non-AF group mainly by: sF (445,5±138,0 versus 403,6±129,6, P<0,002), CRP (15,2±13,1 versus 9,5±7,9, P<0,05), dental state (21,9±9.9 versus 16.2±9.8, P<0,001). For leukocytes number and BSR we do not find a significant difference. By logistic regression, after adjusting for age, we obtained following OR: sF-1,891

Author(s):

Prof Ioan Axente Gutiu

Abstract | PDF

Share this