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Association of Left atrial volume index with N-Terminal Pro-b-Type Natriuretic Peptide Level in Heart Failure Patients with Preserved Ejection Fraction

Heart failure is a major public health issue with a current prevalence of over 23 million worldwide. Epidemiologic studies suggest that nearly one-half of patients with heart failure have a normal ejection fraction that is now termed HFpEF.LA volume has been termed “Glycosylated hemoglobin of Diastolic dysfunction”. Natriuretitic peptides are widely accepted biomarker in HFrEF patients. Now a days, it is   also considered for HFpEF patients for diagnosis & prognosis purpose.

Objectives: To find out the association of Left atrial Volume index (LAVI) with   N-terminal Pro B-type    Natriuretic Peptide level in HFpEF patients.

Methods: Total 120 HFpEF patients were included after considering inclusion and exclusion criteria. Sample population were divided into two groups, Group –I: HFpEF patients with LAVI ≤34ml/m² (n=77); Group –II: HFpEF patients with LAVI >34ml/m² (n=43).

Results: In this study mean NT-pro BNP value of group-I and group-II were 284.45(±24) pg/ml and 1673.99 (±119.90) pg. /ml respectively. Among the Demographic & clinical parameters NYHA class, Hypertension, Diabetes mellitus was statistically significant. Among the echocardiographic parameters, LV hypertrophy,   Mitral inflow E/A ratio, Deceleration time, TDI derived mitral annular eʹ septal velocity, E/ eʹ (septal) ratio, were statistically significant. Statistically significant moderately positive correlation was observed between NT-proBNP level and LAVI value, correlation coefficient(r=0.553, p=0.001).Conclusion:  Elevated LAVI is associated with elevated NT-proBNP level in HFpEF patients & LAVI can be used as a marker of HFpEF.

Author(s):

Dr. Md. Shamim Chowdhury

Registrar, Department of cardiology

National Heart Foundation Hospital &Research institute

 

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