Diabetes mellitus is a rising cause of disease load globally. It is controlled by good adherence to medications. Adherence to anti-diabetic is the challenge in diabetes treatment. However, inconsistency studies were found in Ethiopia. Hence, the aim of this study was to estimate the pooled prevalence of anti-diabetic medication adherence among diabetic patients in Ethiopia.In this systematic review and meta-analysis, we intensely searched PubMed, Google Scholar, Science Direct and Google. To evaluate the overall prevalence, studies stating the prevalence of anti-diabetic adherence and its determinants were included. Data were extracted by a standardized data extraction format prepared in Microsoft Exceland transferred to STATA 11 statistical software for analysis. To assess heterogeneity,the Cochrane Q test statistics and I2 test were used. Studies were exhibited considerable heterogeneity, so a random effect model was used to the Poole prevalence of antidiabetic adherence. Finally, the link between the factors and anti-diabetic medication adherence was assessed.
Conclusion: The overall pooled prevalence of anti-diabetic adherence in Ethiopia, was somewhat high. Age and rural residency were the main determinants of anti-diabetic
adherence in Ethiopia.