Till today pandemia of diabetes mellitus (DM) stays one of the greatest overall clinical issues. 425 million individuals in the World have DM, there will be 629 million of every 2045 . One of the most serious threats of DM is diabetic nephropathy (DN) that creates in 30-40% of diabetic patients and regularly prompts the end-stage renal illness. The different cell types are associated with the kidney harm counting glomerular endotheliocytes, mesangiocytes, podocytes and rounded epitheliocytes - every one of them are the focuses of hyperglycemic injury. Quite a few years back logical intrigue was centered around the mesangium multiplication mesangial network development as a cell and sub-atomic premise of DN ("mesangiocentric" DN idea). Be that as it may, this DN hypothesis didn't clarify plainly the birthplace of proteinuria (PU), particularly enormous. While a full comprehension of the PU systems in DN stays to be accomplished, rising examinations have underscored the urgent job of podocytes in these procedures. It was affirmed by the morphological information, that podocytes changes are principally or optionally embroiled in different proteinuric glomerular illnesses. In addition, there are confirmations of podocytes exhaustion related with the glomerulosclerosis in interminable dynamic glomerulopathies, counting DN. Along these lines, podocytes brokenness and misfortune, their relationship with metabolic and hemodynamic scatters have pulled in logical consideration today so as to discover new strategies for early DN symptomatic and avoidance of ailment movement.